The development and validation of analytical methods is the key to all complex studies. Analytical techniques such as TLC, HPLC, GC-MS and LC-MS/MS are standard.


The Analytical Chemistry department at IES supports all of our departments by analysing study samples and providing additional metabolite data required as part of the product registration process. Aside from this vital role in the company, the analytical team at IES also offers large-scale field testing, including OPEX and five-batch studies.

Method Development, Validation and Dose Verification

IES Ltd develops new analytical methods and offers a full validation service for parent active substances and metabolites for crop, environmental and animal matrices. Dose verifications of studies are additionally performed for our environmental departments at IES. Matrices include samples from ecotoxicology studies (e.g. bees, pollen, nectar, honey, plants), soil samples from field dissipation studies, crop samples from residue studies, soil and water samples from environmental fate studies (laboratory or fate-o-cosm outdoor station), animal tissue samples from feeding studies and samples from storage stability studies.

Metabolite Identification

The identification of metabolites is a critical part of dietary, environmental fate and plant metabolism studies performed to support human and environmental risk assessments. Our mass spectrometrists at IES Ltd have more than 25 years’ expertise in identifying metabolites in biological and environmental samples.

Residue Analysis

To register any plant protection products for the European or worldwide market, it is essential to evaluate possible residue levels in plants and soil. In cooperation with carefully chosen field partners performing the in-life phase across the world, IES offers top expertise in co-ordinating the field studies and conducting the analytical phase (development, validation and implementation of analytical methods and samples measurement) of residue studies.

Five-batch Analysis

Our analytical team has extensive experience and technical knowledge in performing five batch analysis. We use state-of-the-art equipment to conduct studies to the highest possible standard. In close cooperation with our clients we analyse commercial-scale production batches (five or more) of the active ingredient and identify possible impurities.

We offer screening studies including structure elucidation work, up to GLP regulatory studies including method validation to analyse for the active ingredient, related and significant impurities as well as for additional parameters (spectra, water content, etc.). The studies can be carried out to meet the requirements of all international authorities, as given in regulations and guidelines of SANCO, OCSPP, SENASA, IBAMA, APVMA, FAO and IUPAC.

Our equipment includes various forms of HPLC with different detectors, HPLC/MS/MS (including a SCIEX QTRAP® 6500 and accurate mass ThermoFisher Q-Exactive), GC, GC/MS in EI, CI and NCI mode, preparative HPLC and further non-chromatographic equipment required for the tests.

Reading Material

Our Analytical Chemistry Factsheet (.pdf)