We are pleased to share the poster our colleague Arno Wess presented at SETAC in 2021
Title: “OECD TG 201 study results from clindamycin, linezolid, flucloxacillin and metronidazole tests ”
Pharmaceutical residues in freshwater is the subject of a 2019 issue of the OECD studies on water series. It states that mis- and over-use of antibiotics is an important contributing factor of the emergence and spread of antimicrobial resistance – a global health crisis with the potential for enormous health, food security and economic consequences. Another specific concern is that antibiotic modes of actions potentially affect the photosynthetic activity of primary producers and subsequently primary biomass production and carbon dioxide fixation. In 2018, the European Medicines Agency (EMA) has published a new draft guideline intending to implement a new tailored environmental risk assessment scheme for antibiotics. Documented threshold effect levels to three fixed representative species of green algae (Raphidocelis subcapitata) and cyanobacteria (Anabaena flos- aquae and Synechococcus leopoliensis) will be required. This poster presents OECD TG 201 study results from clindamycin, linezolid, flucloxacillin and metronidazole (Loetscher 2019), which complement the literature data to achieve full datasets as demanded by the EMA draft. We discuss cases of significant differences in published literature data , varying results after exposure of 72 h or 96 h and remarkably differing EC10 and NOEC values.
