We are pleased to share the poster our colleague Arno Wess presented at SETAC America in 2020
Title: “NOEC or EC10 for Training Data Sets in QSAR Model Building –Does the Difference Matter?”
As early as 1998 the OECD (Series of Testing and Assessment (STA) No. 10) concluded that the NOEC (No-Observed-Effect-Concentration), as the main summary parameter of aquatic ecotoxicity tests, is inappropriate and should be phased out. It was recommended that the OECD should move towards a regression-based estimation procedure. German authorities have evaluated the subject comprehensively (Kalberlah & Hassauer 2003) and OECD repeated this statement in 2006 (STA 54). Interestingly the first European Medicines Agency (EMA) guidance for the Environmental Risk Assessment (ERA) of human pharmaceuticals, in force since 2006, mentions only the use of NOECs, but the guideline update from 2018 states explicitly that an existing 10%-Effective Concentration(EC10) has to be preferred.
